SB 203580 (CAS No: 152121-47-6), #abs810002
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Price:
Negotiable
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- Total supply:
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Delivery term:
The date of payment from buyers deliver within days
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seat:
Beijing
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Validity to:
Long-term effective
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Last update:
2020-07-12 03:43
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Browse the number:
204
Company Profile
Absin Bioscience Inc.By certification [File Integrity]
Contact:absin2020(Mr.)
Email:
Telephone:
Phone:
Area:Beijing
Address:Beijing
Website:http://www.absin-bio.com/ http://absin2020.sprgjc.com/
Product Details
Catalog-specification | Delivery time | USD price |
abs810002-5mg |
In Stock |
58 |
abs810002-10mg |
In Stock |
70 |
abs810002-100mg |
In Stock |
292 |
Attention: the price only for your reference, the detail price please contact our seller Vecent.
Overview | |
Description |
SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3 (106T) and SAPK4 (106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy. |
Purity |
99% |
Stability & Storage |
Store at -20℃ for one year (Powder); In DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. |
Basic Information | |
Other names |
RWJ 64809; PB 203580; SB203580; SB-203580 |
Appearance |
Lyophilized powder |
Solubility |
DMSO: 43 mg/mL (113.92 mM) |
Biological Activity | |
Target |
p38 MAPK, PKB |
In vitro |
SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells. |
In vivo |
SB203580 protects pig myocardium against ischemic injury in an in vivo model. SB203580 is effective to prevent and treat the disease in MRL/lpr mice model of Systemic lupus erythematosus (SLE). |
References | |
References |
[1] Ferdinand V. Lali, et al. J Biol Chem, 2000, 275(10), 7395-402. [2] Birkenkamp KU, et al. Br J Pharmacol, 2000, 131(1): 99-107. [3] Zhang H, et al. Apoptosis, 2011 |
Chemical Structure
This product is for research use only, not for use in diagnostic prodecures or in human.
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